So you have connection to the Wires-X system, here is a very concise guide of how to get the best out of it...

1. As with simplex listen first, is there already a QSO in progress ?, digital qso's require gaps between overs to make up for latency within the internet.... so we tend to leave a 2-3 second gap between overs...

2. Making a call requires a certain method for you to be heard completely, so key the mic wait a second, give your call and location, wait a second then un-key the mic.... This method should make sure your heard by all listening....

3. Don't try to rush a CQ call take your time, say it twice if needs be, don't give up... don't think that you have not been heard... you probably have, but we are leaving gaps.... or may have to stop working on something before we can get back to you.

4. Never be afraid to speak we all enjoy activity, whats the point on spending all that money just to listen.....
5. What about RULES?.. We are all Licensed Amateurs, we all know the operating rules and procedure's, its the same for everybody.
WIRES (Wide-coverage Internet Repeater Enhancement System) is an Internet communication system which expands the range of amateur radio communication. For WIRES-X, an amateur node station connecting to the Internet is used as the access point and connects the wireless communication to the Internet. Users' stations can communicate with other amateur stations all over the world using a node within the radio wave range.
WIRES-X supports the C4FM digital and the clear and crisp voice technology enables high sound quality. By repeating C4FM digital data as it is via the Internet, users can enjoy clear voice communications even if they are thousands of miles away each other.

Utilizing the digital communication, the WIRES-X operation is simple, easy and user friendly.
Varieties of the new functions as well as voice communications expands opportunities for enjoyment of ham station operation.
The WIRES-X node consists of a PC, the WIRES-X connection kit HRI-200 and a transceiver and is a repeater station used as the WIRES-X access point to connect the Internet and the wireless signal alternatively.
The WIRES-X node can open and run a community space "room" where multiple nodes can connect at the same time. Furthermore, the news functions allows you to upload/download messages or images to/from each node or room.
Follow the link to the  Wires X Node ID & Room ID List
WIRES-X automatically connects to nodes and rooms via the Internet. No more need to verify connection IDs or transmit cumbersome DTMF connection codes.
Information about nodes and rooms is exchanged via C4FM Digital signaling. Thanks to automatic reconnection to the previous contact, all you need to do is press PTT and start talking.
Easily search for new nodes and rooms, and initiate communication promptly when you find an ID that captures your interest.
Currently active nodes and rooms can be searched in real time, and viewed on the display of your transceiver. The display list is sorted according to the number of stations currently connected to the room, in other words by popularity. This lets you quickly find other active stations to communicate with.
Node owners can freely create a room ID using letters and numbers. The ID works a bit like the name of a person. Easy to understand, meaningful names, unique names, memorable names... all are possible and can be used in a targeted search. A history of previous nodes and rooms, and a memory function with five categories makes it a snap to find and connect with a particular ID.